PLA2
An abbreviation for Phospholipase A2, which is a key enzyme involved in the release of arachidonic acid (AA) from the cell membrane. Inhibition of PLA2 by lipocortins causes a decrease in inflammation.
MoreAn abbreviation for Phospholipase A2, which is a key enzyme involved in the release of arachidonic acid (AA) from the cell membrane. Inhibition of PLA2 by lipocortins causes a decrease in inflammation.
MoreA key enzyme involved in the release of arachidonic acid (AA) from the cell membrane. Inhibition of PLA2 by lipocortins causes a decrease in inflammation.
MoreA class of prostaglandins that is known to have pro-inflammatory effects such as increasing pain, decreasing oxygen flow, constricting airways, and increasing inflammation.
MoreClasses of prostaglandins that are known to have anti-inflammatory effects such as decreasing pain, increasing oxygen flow, dilating airways, and decreasing inflammation.
MoreThe reaction that occurs when the immune system fights back against injury or infection in a particular part of the body. That part of the body is called ‘inflamed’, and may look red and swollen. Also known as inflammation.
MoreA medicine that helps relieve pain, fever, and inflammation. Ibuprofen stops prostaglandin synthesis and acts as a PPAR-gamma activator. Common brand names include Motrin® and Advil®.
MoreAn enzyme that leads to the production of leukotrienes, which are chemicals that contribute significantly to inflammation.
MoreAn enzyme that breaks down heme and plays various roles in the processes of oxidative stress and inflammation.
MoreAbbreviation for nonsteroidal anti-inflammatory drugs, which are compounds that significantly reduce the inflammatory response by interfering with the cyclooxygenase pathway, reducing the level of compounds that allow inflammation to occur.
MoreCompounds that significantly reduce the inflammatory response by interfering with the cyclooxygenase pathway, reducing the level of compounds that allow inflammation to occur.
MoreAn enzyme that produces leukotrienes, chemicals that contribute significantly to inflammation.
MoreOne form of the cyclooxygenase enzyme. COX-2 enzymes are often produced during inflammatory responses and are responsible for the synthesis of prostaglandins that mediate inflammation.
MoreA chronic autoimmune disease characterized by inflammation in the brain.
MoreA drug widely used for relieving pain and reducing fever in adults. It also relieves mild itching and reduces swelling and inflammation. Use of aspirin by children has been linked to the occurrence of a disorder known as Reye’s Syndrome.
MoreA disease characterized by joint inflammation. Joint injury can be caused by trauma or aging. The general term arthritis includes over 100 kinds of diseases, most of which last for life. In many forms of arthritis, injury is caused by the uncontrolled inflammation of autoimmune disease, in which the immune…
MoreReducing inflammation. Many substances, including the drug aspirin, have anti-inflammatory effects.
MoreA skin inflammation affecting approximately 80% of people between the ages of 12 and 24. Located in each hair follicle is a gland that lubricates the skin. If some oil gets trapped in the gland, bacteria multiply in the pit and the skin becomes inflamed.
MoreA class of powerful inflammatory mediators. Leukotrienes are important in inflammation and allergic reactions because of their ability to constrict blood vessels and attract various types of immune cells.
MoreThere is ample evidence that Huntington’s disease is associated with a specific genetic mutation that produces an expanded polyglutamine chain in the huntingtin protein. This mutation causes huntingtin to become a misfolded protein with an altered shape. One of the hallmarks of HD is the build-up of short, broken fragments…
MoreDrug Summary: Ginkgo biloba has been shown to have antioxidant and anti-inflammatory properties. Because free radicals and inflammation are believed to be factors involved in the progression of HD, Ginkgo biloba may help in alleviating the symptoms of HD. However, no studies have been done yet on the effects of…
MoreDrug Summary: Folic acid, also known as vitamin B11 and naturally found in the form of folate, is important in many biological processes. A recent study conducted over three years with healthy adults 50-70 years old showed that folic acid supplements equal to twice the recommended daily value improved memory…
MoreUpdate: a 2010 study of Minocycline, called DOMINO, concluded that minocycline does not warrant further study for the treatment of HD. 114 patients who had mild to moderate HD were treated with either 200 mg of minocycline or a placebo every day for 18 months. The study measured patient’s improvement…
MoreDrug Summary: Omega-3 fatty acids are a form of fatty acids that our body derives from food. Studies have discovered that omega-3 fatty acids have anti-inflammatory effects due to their ability to convert into anti-inflammatory prostaglandins. In addition, omega-3 fatty acids can decrease the production of inflammatory prostaglandins, resulting in…
MoreDrug Summary: NSAIDs (Non-steroidal anti-inflammatory drugs) are compounds that significantly reduce the inflammatory response. Common examples of NSAIDs include ibuprofen (Motrin®, Advil®) and naproxen (Aleve®). Studies have shown that chronic inflammatory responses occur in vulnerable areas of the brains of HD patients. These inflammatory responses are believed to be a…
MoreDrug Summary: Glucocorticoids are powerful anti-inflammatory compounds that have the ability to inhibit all stages of the inflammatory response. Common glucocorticoids include prednisone, dexamethasone, and hydrocortisone. While glucocorticoids are widely used as drugs to treat various inflammatory conditions, prolonged glucocorticoid use may have adverse side effects such as immunosuppression, fluid…
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