Search Results For inflammation

About Inflammation

Inflammation, what we commonly know as the swelling, redness, heat, and pain that often accompany injuries, is one of our body’s most important natural defense mechanisms against internal and external threats. The inflammatory process protects our body from damage and disease by releasing cells and mediators that combat foreign substances…

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inflammation

The reaction that occurs when the immune system fights back against injury or infection in a particular part of the body. That part of the body is called ‘inflamed’, and may look red and swollen.

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Biomarkers: The Clues in us

Biomarkers: The Clues in us
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Recent research has focused on tackling the issue of the unmet medical need of an objective and quantitative biomarker for Huntington’s disease (HD). The discovery of biomarkers specific to the different stages of HD could help physicians monitor the physical changes of an individual’s HD during asymptomatic stages, and help…

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2018 HOPES conference discussed up-and-coming treatments, stories of resilience

The 17th annual HOPES conference highlighted the clinical potential for targeting the DNA and RNA of the mutant huntingtin gene, as well as the importance of advocacy in transforming the Huntington’s disease community. University of California, Davis doctoral candidate Peter Deng discussed using artificial transcription factors to “switch off” the…

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Paramedic Stem Cells Show Potential as a Treatment for Huntington’s Disease in Mouse Studies

Background Huntington’s Disease (HD) is a heritable neurodegenerative disease characterized by significant neuron loss in the striatum, a region of the brain primarily involved in voluntary movement, followed by widespread neuron loss in other brain regions. More information on the basics of HD, including symptoms and genetics, is available here.…

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World Congress 2013 – Premanifest HD

In September 2013, several HOPES student researchers attended the Huntington’s Disease World Congress, held in Rio de Janeiro, Brazil. Summaries of the all the sessions attended can be found in the Conferences and Conventions section of our site. The HOPES trip to the 2013 World Congress received partial support from…

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Trojan Therapy

The blood-brain barrier (BBB) is a layer of cells that block most molecules from entering the brain in order to protect this sensitive organ from external invaders. It does its job so well that delivering treatments to the brain is extremely difficult and poses a great challenge to drug development.…

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The Immune System and HD

The human immune system consists of various cells circulating in blood and lymph vessels that can localize to sites of damage, injury, or infection and help in repairing damaged cells and destroying foreign or unhealthy substances. The immune system is complex, involving innate mechanisms such as inflammation and fever as…

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Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are a type of multipotent stem cell, meaning that they can give rise to many but not all types of cells in the body. MSCs secrete substances, including cytokines and growth factors, that are essential to cell growth and help repair damaged tissue. Researchers are still…

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Diet and Neurogenesis

A novel track of research has unearthed new meaning to the old adage “you are what you eat”. Research suggests that our diet plays a role in neurogenesis, the process by which we produce new neurons. Therefore, a diet rich in “brain food” may promote neurogenesis and thereby might repair…

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PPAR-gamma

Proteins that inhibit the expression of genes that code for proteins involved in inflammation.

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pneumonia

An inflammation of the lungs that can be caused by infection or other environmental irritants.

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platelet-activating factor (PAF)

A compound that reduces inflammation by increasing permeability of blood vessels and contracting various involuntary muscles such as those in airways.

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PLA2

An abbreviation for Phospholipase A2, which is a key enzyme involved in the release of arachidonic acid (AA) from the cell membrane. Inhibition of PLA2 by lipocortins causes a decrease in inflammation.

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phospholipase A2 (PLA2)

A key enzyme involved in the release of arachidonic acid (AA) from the cell membrane. Inhibition of PLA2 by lipocortins causes a decrease in inflammation.

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PG2

A class of prostaglandins that is known to have pro-inflammatory effects such as increasing pain, decreasing oxygen flow, constricting airways, and increasing inflammation.

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PG1 and PG3

Classes of prostaglandins that are known to have anti-inflammatory effects such as decreasing pain, increasing oxygen flow, dilating airways, and decreasing inflammation.

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