tetrabenazine
A drug that lowers levels of the neurotransmitter dopamine to treat chorea, or the uncontrollable twisting motions that affect many people affected by HD.
MoreA drug that lowers levels of the neurotransmitter dopamine to treat chorea, or the uncontrollable twisting motions that affect many people affected by HD.
MoreTetrabenazine Chorea is one of the most common and debilitating motor symptoms experienced by people with Huntington’s Disease. Tetrabenazine (TBZ) has been the drug of choice for treating chorea in 10 countries for more than a decade. However, TBZ has not been widely used in the U.S. because, until recently,…
MorePsychiatric Problems are a Part of HD Pathology Huntington’s disease is conventionally recognizable for its motor implications. Indeed, chorea, or involuntary, irregular, and unpredictable muscle movement, is a hallmark symptom of the disease. However, psychiatric and behavioral symptoms are also important presenting signs of HD.1 Psychiatric symptoms are incredibly common…
MoreFor many years, the question of how to best use anesthesia in people with Huntington’s Disease (HD) has puzzled medical professionals. With an occurance of about 5 cases per 100,000 people in the US and Europe, HD is considered to be rare, and anesthesiologists are not likely to come across…
MoreNeuroleptic malignant syndrome (NMS) is a rare but potentially life-threatening syndrome that can emerge in response to neuroleptic medications, such as tetrabenazine or deutetrabenazine. Neuroleptic medications, also known as antipsychotics, are broadly used to treat confusion and agitation and allow for normal movement. Symptoms of NMS include mental status change,…
MoreWhat are clinical trials? In order for any drug or treatment to be approved for human use by the FDA, it must first successfully pass clinical trials. A clinical trial is a medical or health-related research study in humans that follows a strict protocol in a carefully monitored, scientifically controlled…
MoreOn the 19th of November, 2016, the University of California San Francisco’s Memory and Aging Center hosted their 13th Annual Huntington Disease Research Symposium. This symposium featured the latest in research and therapies, allowing patients and families more information about combating the disease. A recorded video of the symposium is…
More2016 HDSA Convention Summary Article Strategies for Managing Depression in HD Families Presentation Title: Strategies for Managing Depression June 3, 2016 Presenter: Dr. Karen Anderson, MD — Director of the HDSA Center of Excellence at Georgetown Hospital in Washington, D.C. and psychiatrist specializing in neuropsychiatry. Panelists: Doris, Anne, and Cary…
MoreOn April 9th, HOPESters Natty and Caitlin attended Help4HD’s 3rd annual symposium in Sacramento, California. The all-day event featured a wide range of presentations from speakers representing academic institutions, pharmaceutical companies, and research groups. The event honored the work and retirement of Terry Tempkin, RNC, MSN, ANP. Terry is…
MoreMadam Secretary; Season 2, Episode 6; Catch and Release Episode Recap Madam Secretary is a fictional television drama that follows the work of Elizabeth McCord, the United States’ Secretary of State. In this particular episode, the State Department learns that a new leader of ISIS has released a video showing the beheading…
MoreFollowing her great success with Still Alice and Alzheimer’s disease, neuroscientist and author Lisa Genova attempts to accurately portray the disease experience of a Huntington’s disease (HD) family in her latest novel, Inside the O’Briens. Unlike most media outlets, Genova goes to great lengths to understand the disease, both…
MoreIn September 2013, several HOPES student researchers attended the Huntington’s Disease World Congress, held in Rio de Janeiro, Brazil. Summaries of the all the sessions attended can be found in the Conferences and Conventions section of our site. The HOPES trip to the 2013 World Congress received partial support…
MoreHOPES summary of the talks from scientists and clinicians Note: This article includes references to Dimebon, which is no longer being considered as a potential treatment for HD after the HORIZON clinical trial showed that Dimebon was not better than a placebo. For more information, click here F. Clum, C.…
MoreDrug Summary: Pridopidine, also known as Huntexil or ACR-16, is a dopamine stabilizer intended to improve voluntary movements and reduce chorea. Initial clinical trials – the MermaiHD and HART studies – show promising results, but drug regulation agencies have requested another trial before pridopidine can be sold to the general…
MoreThe brand name under which Lundbeck markets the drug Tetrabenazine in the U.S.
MoreVesicular monoamine transporters (VMATs) are proteins in neurons that help put neurotransmitters into vesicles so they can be released into the synapse. VMATs can be inhibited by the drugs tetrabenazine and deutetrabenazine.
MoreHave you ever wondered how new medicines are discovered? The process of going from an important discovery in a science laboratory to a successful drug available to the public is complex, costly, and time-consuming. This process is often referred to as Research and Development, or the R&D pipeline. It has…
MoreHuntington’s disease (HD), an inherited neurodegenerative disorder, damages specific areas of the brain, resulting in movement difficulties as well as cognitive and behavioral changes. HD is often characterized by the motor symptoms that it causes. Huntington’s disease (HD), an inherited neurodegenerative disorder, damages specific areas of the brain, resulting in…
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