coenzyme Q10
Also called ubiquinone, or CoQ10. CoQ10 is a nutritional supplement that acts as an antioxidant and is an important molecule involved in the respiratory chain.
MoreCoenzyme-Q10
Huntington's Disease (HD) is associated with a genetic mutation that results in an expanded polyglutamine chain in the huntingtin protein. In HD, huntingtin becomes a misfolded protein, which can cause many problems for the nerve cell. Scientists have not yet found a straightforward way to explain how a single genetic…
MoreClinical Trials on Huntington’s disease
What are clinical trials? In order for any drug or treatment to be approved for human use by the FDA, it must first successfully pass clinical trials. A clinical trial is a medical or health-related research study in humans that follows a strict protocol in a carefully monitored, scientifically controlled…
MoreWeight Loss: Demystifying a Medical Mystery
While Huntington’s disease is traditionally thought of as a disease of the brain, its effects are much more widespread: many people with HD lose a dangerous amount of weight, complicating a disease that is already complicated enough. Although weight loss is one of the most serious non-neurological problems of HD,…
MoreRemacemide
Drug Summary: Remacemide (RMC) is a drug that HD researchers hope can alleviate glutamate toxicity in the brains of HD patients. Remacemide is an NMDA antagonist – it inhibits the binding of glutamate to NMDA receptors, preventing glutamate from exerting its toxic effects on the nerve cell. Although, it has…
MoreNicotinamide
Drug Summary: Nicotinamide (also referred to as Vitamin B3) is believed to cause improvements in energy production due to its role as a precursor of NAD (nicotinamide adenosine dinucleotide), an important molecule involved in energy metabolism. Increasing nicotinamide concentrations increase the available NAD molecules that can take part in energy…
MoreMore Research Institutions
Readers of our website sometimes ask, "Where does all the research summarized by HOPES come from?" Here follows a list of some main contributors to HD research, along with some of their recent studies, clustered in five categories:
We've also included some news articles highlighting the key discoveries. You…
MoreHennepin County Medical Center of Excellence
In July 2008, HOPES researcher Tiffany Wang visited the Huntington’s Disease Society of America Center of Excellence located at the Hennepin County Medical Center (HCMC) in Minneapolis, Minnesota. The Center of Excellence serves approximately four hundred Huntington’s Disease (HD) patients and families from Minnesota, North Dakota, South Dakota, Northern Iowa…
MoreVitamin E
Drug Summary: Vitamin E is a lipid-soluble vitamin that protects cell membranes and other lipid-containing substances in the body from free radical damage by interacting directly with free radicals and neutralizing them. Vitamin E could potentially help treat neurodegenerative diseases such as HD by protecting nerve cell membranes (which are…
MoreThe Huntington’s Disease Pipeline
Have you ever wondered how new medicines are discovered? The process of going from an important discovery in a science laboratory to a successful drug available to the public is complex, costly, and time-consuming. This process is often referred to as Research and Development, or the R&D pipeline. It has…
MoreJohns Hopkins Center of Excellence
In April 2007, HOPES researcher Justine Seidenfeld visited the Baltimore Huntington’s Disease Center (BHDC) in the Department of Psychiatry at the Johns Hopkins University School of Medicine in Baltimore, MD. The BHDC has been designated as a Center of Excellence by the Huntington’s Disease Society of America (HDSA). Centers of…
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